Fourth, correlation between Hi/Hr and 1/VSI is analysed by using linear, quadratic, and cubic models.

Third, different VSI values are obtained from the ki of different viruses dividing by the kr of MS2-phage. Second, the inactivation rate constants of MS2-phage are statistically analysed at 3, 4, 5, and 6 Logâ€‰I levels. First, the first-order inactivation rate constants are determined by regression analysis between Logâ€‰I and fluence required. There are four major steps in deriving the equation between Hi/Hr and 1/VSI. For example, it can be used to rank the UV disinfection sensitivity of viruses in reference to MS2-phage. VSI has wide applications in research, design, and validation of UV disinfection systems. MS2-phage is chosen as the reference virus because it is recommended as a virus indicator during UV reactor design and validation by the US Environmental Protection Agency. Virus Sensitivity Index of UV disinfection.Ī new concept of Virus Sensitivity Index (VSI) is defined as the ratio between the first-order inactivation rate constant of a virus, ki, and that of MS2-phage during UV disinfection, kr. The advantage of this method is the possibility of integration of organic layers as well as other temperature- sensitive layers into a microfluidic glass device. In this way a microfluidic glass chip was fabricated that could be used for performing surface plasmon resonance measurements without signs of leakage.

To avoid filling the fluidic channels with the glue, a stamping process was developed which allows the selective application of a thin glue layer. The wafer with the fluidic structures was bonded to a sensor wafer with gold pads by means of adhesive bonding, utilizing an UV-curable glue layer. M.Ī method for the bonding of a microfluidic device at room temperature is presented. Fabrication of a microfluidic chip by UV bonding at room temperature for integration of temperature- sensitive layers

Alex downs scida